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Chunk #18 — RESULTS — Experiment 2: The Effect of D-Lys3-GHRP-6 on alcohol intake

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Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons.
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D-Lys3-GHRP-6 showed a significantly reduced intake of alcohol (2.49 ± 0.32 g/kg) when compared to the saline-injected mice (4.99 ± 0.38) [F(1,27) = 24.87, p < 0.0001] during the 4 h access period. The resulting blood ethanol concentrations after D-Lys3-GHRP-6 (63.64 ± 11.67 mg%) were also significantly lower than after saline injections (114.82 ± 21.28 mg%) [F(1,27) = 4.27, p = 0.0484] (Fig. 2B).