With respect to tolerability, in children and adolescents, only guanfacine and amphetamines were less well tolerated than placebo (figure 3, table 2). In adults, modafinil, amphetamines, methylphenidate, and atomoxetine were inferior to placebo (no data were available for guanfacine and clonidine). No differences in tolerability were noted between active drugs, in children, adolescents, and adults.
