Chunk #27 — Background — Details of data simulation — 2. Areas with LD/unique characteristics

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Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

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2. Locus D2: SNP loci B03T3056-B03T3068. There is LD in this region. The disease-carrying haplotypes are defined by sorting by haplotype structure and then choosing adjacent haplotypes. 194/1003 haplotypes in this region carry disease alleles. Disease mutation is at the end of the chromosome.