Most interestingly, the CSD method has also been found to be sensitive in differentiating two types of patient groups. Kayser et al. (2012) found that CSD related to the N1 component during a recognition and working memory paradigm was substantially reduced in schizophrenic patients with auditory hallucinations compared to patients without auditory hallucinations and healthy controls. However, CSD activation deficits observed in schizophrenics did not have any impact on inter-hemispheric transmission times (IHTT) as observed by Whitford et al. (2011); they reported that there was no difference between schizophrenic patients and controls in the IHTT (computed by ipsilateral minus contralateral latency) in P1 and N1 components of the CSD transformed ERP waveforms during a visual target detection task, suggesting that schizophrenics may not have problems related to neural conduction speed. Taken together, it is clear that the CSD method has been successfully applied in schizophrenia to understand the neurocognitive deficits reported in the literature, to predict transition from prodromal stage to psychosis, and to differentiate two sets of symptomatology within the schizophrenic diagnosis.
