Internalizing disorders, such as depression and anxiety, have been linked to relative right-sided resting frontal EEG asymmetry among adults and infants of afflicted mothers (for a meta-analytic review, see Thibodeau et al., 2006), and therefore this abnormality has been suggested to be an endophenotype for these disorders. Although a few studies have identified anomalous CSD features of EEG and ERP activations in depression, such studies in other internalizing disorders such as anxiety disorders are rare (See Table 1, section 3). Using a surface Laplacian method, Bauer and Hesselbrock (2002) attempted to discern whether abnormalities related to frontal EEG asymmetry in depressed individuals are due to depression per se or the result of an interaction between depression and either of two family history variables—a family history of alcoholism or a family history of depression. While no significant main or interactive effects of a family history of depression, topographic analyses of surface Laplacian showed that the effects of depression could be localized to the right frontal region, whereas the effects of a family history of alcoholism were localized to the left frontal
