Despite these limitations, the current study provides important insights into the role of parent–child closeness during adolescence on brain function and risky drinking behaviors among high-risk offspring. The current findings also underscore the importance of prospective and longitudinal neurophysiological studies in associating parent–child relationship during critical developmental junctures with offspring brain development and behavior. Furthermore, this work also enhances our understanding of how family life can potentially buffer against AUD risk and identifies one of the key aspects in one’s home environment for planning of prevention and intervention strategies.