Associations of parent-adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder.
paper
Primary
Public
- Authors
- Pandey, Gayathri; Kuo, Sally I-Chun; Horne-Osipenko, Kristina A; Pandey, Ashwini K; Kamarajan, Chella; de Viteri, Stacey Saenz; Kinreich, Sivan; Chorlian, David B; Kuang, Weipeng; Stephenson, Mallory; Kramer, John; Anokhin, Andrey; Zang, Yong; Kuperman, Samuel; Hesselbrock, Victor; Schuckit, Marc; Dick, Danielle; Chan, Grace; McCutcheon, Vivia V; Edenberg, Howard; Bucholz, Kathleen K; Meyers, Jacquelyn L; Porjesz, Bernice
- Year
- 2023
- Journal
- Alcohol, clinical & experimental research
- PMID
- 36680783
- DOI
- 10.1111/acer.14973
- PMCID
- PMC10910630
BACKGROUND: Parents impact their offspring's brain development, neurocognitive function, risk, and resilience for alcohol use disorder (AUD) via both genetic and socio-environmental factors. Individuals with AUD and their unaffected children manifest low parietal P3 amplitude and low frontal theta (FT) power, reflecting heritable neurocognitive deficits associated with AUD. Likewise, children who experience poor parenting tend to have atypical brain development and greater rates of alcohol problems. Conversely, positive parenting can be protective and critical for normative development of self-regulation, neurocognitive functioning and the neurobiological systems subserving them. Yet, the role of positive parenting in resiliency toward AUD is understudied and its association with neurocognitive functioning and behavioral vulnerability to AUD among high-risk offspring is less known. Using data from the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 1256, mean age [SD] = 19.25 [1.88]), we investigated the associations of closeness with mother and father during adolescence with offspring P3 amplitude, FT power, and binge drinking among high-risk offspring. METHODS: Self-reported closeness with mother and father between ages 12 and 17 and binge drinking were assessed using the Semi-Structured Assessment for the Genetics of Alcoholism. P3 amplitude and FT power were assessed in response to target stimuli using a Visual Oddball Task. RESULTS: Multivariate multiple regression analyses showed that closeness with father was associated with larger P3 amplitude (p = 0.002) and higher FT power (p = 0.01). Closeness with mother was associated with less binge drinking (p = 0.003). Among male offspring, closeness with father was associated with larger P3 amplitude, but among female offspring, closeness with mother was associated with less binge drinking. These associations remained statistically significant with father's and mothers' AUD symptoms, socioeconomic status, and offspring impulsivity in the model. CONCLUSIONS: Among high-risk offspring, closeness with parents during adolescence may promote resilience for developing AUD and related neurocognitive deficits albeit with important sex differences.
Top panel: Bar graph of association between offspring target parietal (Pz) P3 amplitude and low versus high closeness with father during adolescence (dichotomized using the median split) in male (left) and female (right) offspring. Bottom panel: Surface 2D head plots illustrate visual P3 amplitudes among male (left) and female (right) offspring for low versus high closeness with father. Note that while females had larger P3 amplitude compared to males, greater closeness with father was significantly associated with larger P3 amplitude among male but not female offspring. *p < 0.05. Similarly, closeness with father was also associated with higher frontal theta power to targets during the oddball task.
1–20 of 48
Next →
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| BachmanMD & BernatEM (2018) Independent contributions of theta and delta time-frequency activity to the visual oddball P3b. International Journal of Psychophysiology, 128, 70–80.29574233 10.1016/j.ijpsycho.2018.03.010PMC5960636 | — | — | — |
| BanksDE, FaidleyaMT, SmithGT & ZapolskiTCB (2020) Racial/ethnic differences in the time-varying association between alcohol expectancies and drinking during the transition from childhood to adolescence. Journal of Ethnicity in Substance Abuse, 19, 371–387.30346911 10.1080/15332640.2018.1520174PMC6476698 | — | — | — |
| BegleiterH, PorjeszB, BihariB & KissinB (1984) Event-related brain potentials in boys at risk for alcoholism. Science, 225, 1493–1496.6474187 10.1126/science.6474187 | — | — | — |
| BelskyJ & PluessM (2009) Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin, 135, 885–908.19883141 10.1037/a0017376 | — | — | — |
| BergeJ, SundellK, OjehagenA & HakanssonA (2016) Role of parenting styles in adolescent substance use: results from a Swedish longitudinal cohort study. BMJ Open: Addiction Research, 6, e008979.10.1136/bmjopen-2015-008979PMC473530926769781 | — | — | — |
| BernierA, CarlsonSM, DeschenesM & Matte-GagneC (2012) Social factors in the development of early executive functioning: a closer look at the caregiving environment. Developmental Science, 15, 12–24.22251288 10.1111/j.1467-7687.2011.01093.x | — | — | — |
| BickJ & NelsonCA (2016) Early adverse experiences and the developing brain. Neuropsychopharmacology, 41, 177–196.26334107 10.1038/npp.2015.252PMC4677140 | — | — | — |
| BrennanGM & Baskin-SommersAR (2018) Brain-behavior relationships in externalizing: P3 amplitude reduction reflects deficient inhibitory control. Behavioural Brain Research, 337, 70–79.28966148 10.1016/j.bbr.2017.09.045 | — | — | — |
| BrodyGH, BeachSR, PhilibertRA, ChenYF, LeiMK, MurryVM (2009) Parenting moderates a genetic vulnerability factor in longitudinal increases in youths’ substance use. Journal of Consulting and Clinical Psychology, 77, 1–11.19170449 10.1037/a0012996PMC2868377 | — | — | — |
| BucholzKK, McCutcheonVV, AgrawalA, DickDM, HesselbrockVM, KramerJR (2017) Comparison of parent, peer, psychiatric, and cannabis use influences across stages of offspring alcohol involvement: evidence from the COGA prospective study. Alcoholism, Clinical and Experimental Research, 41, 359–368.28073157 10.1111/acer.13293PMC5272776 | — | — | — |
| DandashO, CherbuinN, SchwartzO, AllenNB & WhittleS (2021) The long-term associations between parental behaviors, cognitive function and brain activation in adolescence. Scientific Reports, 11, 11120.34045502 10.1038/s41598-021-90474-2PMC8160361 | — | — | — |
| DozierM, LindhiemO, LewisE, BickJ, BernardK & PelosoE (2009) Effects of a Foster parent training program on young Children’s attachment behaviors: preliminary evidence from a randomized clinical trial. Child and Adolescent Social Work Journal, 26, 321–332.22065891 10.1007/s10560-009-0165-1PMC3209265 | — | — | — |
| EuserAS, EvansBE, Greaves-LordK, HuizinkAC & FrankenIH (2013) Parental rearing behavior prospectively predicts adolescents’ risky decision-making and feedback-related electrical brain activity. Developmental Science, 16, 409–427.23587039 10.1111/desc.12026 | — | — | — |
| FieldA (2009) Discovering statistics using SPSS, 3rd edition. London: Sage Publishing House. | — | — | — |
| GardAM, HeinTC, MitchellC, Brooks-GunnJ, McLanahanSS, MonkCS (2022) Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence. Development and Psychopathology, 34, 981–996.33487207 10.1017/S0954579420001583PMC8310533 | — | — | — |
| GrossmannKG, GrossmannKE, KindlerH & ZimmermannP (2008) A wider view of attachment andexploration. In: CassidyJS & ShaverPR (Eds.) Handbook of attachment: theory, research, and clinical applications, Vol. 2. New York: The Guilford Press. | — | — | — |
| GryczkowskiMR, JordanSS & MercerSH (2010) Differential relations between mothers’ and fathers’ parenting practices and child externalizing behavior. Journal of Child and Family Studies, 19, 539–546. | — | — | — |
| HammondMA, KhuranaA & StormshakEA (2021) Adolescent measures of family socioeconomic status: reliability, validity, and effects on substance use behaviors in adolescence and young adulthood. Preventive Medicine Reports, 21, 101317.33511027 10.1016/j.pmedr.2021.101317PMC7815999 | — | — | — |
| HanniganLJ, McAdamsTA, PlominR & EleyTC (2017) Parent- and child-driven effects during the transition to adolescence: a longitudinal, genetic analysis of the home environment. Developmental Science, 20, e12432.27320336 10.1111/desc.12432PMC5599952 | — | — | — |
| HarperJ, MaloneSM & IaconoWG (2021) Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use. Psychological Medicine, 51, 416–425.31736455 10.1017/S0033291719003258PMC7231637 | — | — | — |
| HillSY, ShenS, LockeJ, SteinhauerSR, KonickyC, LowersL (1999) Developmental delay in P300 production in children at high risk for developing alcohol-related disorders. Biological Psychiatry, 46, 970–981.10509180 10.1016/s0006-3223(99)00032-3 | — | — | — |
| HochgrafAK, FoscoGM, LanzaST & McHaleSM (2021) Developmental timing of parent–youth intimacy as a protective factor for adolescent adjustment problems. Journal of Family Psychology, 35, 916–926.33956469 10.1037/fam0000864PMC8478700 | — | — | — |
| IaconoWG & MaloneSM (2011) Developmental Endophenotypes: indexing genetic risk for substance abuse with the P300 brain event-related potential. Child Development Perspectives, 5, 239–247.22247735 10.1111/j.1750-8606.2011.00205.xPMC3254094 | — | — | — |
| KiffCJ, LenguaLJ & ZalewskiM (2011) Nature and nurturing: parenting in the context of child temperament. Clinical Child and Family Psychology Review, 14, 251–301.21461681 10.1007/s10567-011-0093-4PMC3163750 | — | — | — |
| KingV, BoydLM & PraggB (2018) Parent-adolescent closeness, family belonging, and adolescent well-being across family structures. Journal of Family Issues, 39, 2007–2036.29805189 10.1177/0192513X17739048PMC5966042 | — | — | — |
| KokR, ThijssenS, Bakermans-KranenburgMJ, JaddoeVW, VerhulstFC, WhiteT (2015) Normal variation in early parental sensitivity predicts child structural brain development. Journal of the American Academy of Child and Adolescent Psychiatry, 54, 824–831.26407492 10.1016/j.jaac.2015.07.009 | — | — | — |
| Kopala-SibleyDC, CyrM, FinsaasMC, OraweJ, HuangA, TottenhamN (2020) Early childhood parenting predicts late childhood brain functional connectivity during emotion perception and reward processing. Child Development, 91, 110–128.30102429 10.1111/cdev.13126PMC6374219 | — | — | — |
| KuendigH & KuntscheE (2006) Family bonding and adolescent alcohol use: moderating effect of living with excessive drinking parents. Alcohol and Alcoholism, 41, 464–471.16624840 10.1093/alcalc/agl018 | — | — | — |
| LansfordJE, RothenbergWA, JensenTM, LippoldMA, BacchiniD, BornsteinMH (2018) Bidirectional relations between parenting and behavior problems from age 8 to 13 in nine countries. Journal of Research on Adolescence, 28, 571–590.30515947 10.1111/jora.12381PMC6282841 | — | — | — |
| LarsenB & LunaB (2018) Adolescence as a neurobiological critical period for the development of higher-order cognition. Neuroscience and Biobehavioral Reviews, 94, 179–195.30201220 10.1016/j.neubiorev.2018.09.005PMC6526538 | — | — | — |
| LatendresseSJ, RoseRJ, VikenRJ, PulkkinenL, KaprioJ & DickDM (2008) Parenting mechanisms in links between parents’ and adolescents’ alcohol use behaviors. Alcoholism, Clinical and Experimental Research, 32, 322–330.18162066 10.1111/j.1530-0277.2007.00583.xPMC2504716 | — | — | — |
| LeeH & SchaferM (2021) Are positive childhood experiences linked to better cognitive functioning in later life?: examining the role of life course pathways. Journal of Aging and Health, 33, 217–226.33228449 10.1177/0898264320972547PMC7906946 | — | — | — |
| LeesB, MeredithLR, KirklandAE, BryantBE & SquegliaLM (2020) Effect of alcohol use on the adolescent brain and behavior. Pharmacology Biochemistry and Behavior, 192, 172906.32179028 10.1016/j.pbb.2020.172906PMC7183385 | — | — | — |
| LiF, TaoQ, PengW, ZhangT, SiY, ZhangY (2020) Inter-subject P300 variability relates to the efficiency of brain networks reconfigured from resting-to task-state: evidence from a simultaneous event-related EEG-fMRI study. NeuroImage, 205, 116285.31629829 10.1016/j.neuroimage.2019.116285 | — | — | — |
| LiJB, WillemsYE, StokFM, DekovicM, BartelsM & FinkenauerC (2019) Parenting and self-control across early to late adolescence: a three-level meta-analysis. Perspectives on Psychological Science, 14, 967–1005.31491364 10.1177/1745691619863046 | — | — | — |
| LipariRN & Van HornSL (2017) Children living with parents who have a substance use disorder, in series children living with parents who have a substance use disorder. The CBHSQ report. Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration.29144715 | — | — | — |
| MajdandzicM, MollerEL, de VenteW, BogelsSM & van den BoomDC (2014) Fathers’ challenging parenting behavior prevents social anxiety development in their 4-year-old children: a longitudinal observational study. Journal of Abnormal Child Psychology, 42, 301–310.23812638 10.1007/s10802-013-9774-4 | — | — | — |
| MartelMM, LevinsonCA, LeeCA & SmithTE (2017) Impulsivity symptoms as core to the developmental externalizing Spectrum. Journal of Abnormal Child Psychology, 45, 83–90.27017822 10.1007/s10802-016-0148-6PMC5040618 | — | — | — |
| MascaroJS, RentscherKE, HackettPD, MehlMR & RillingJK (2017) Child gender influences paternal behavior, language, and brain function. Behavioral Neuroscience, 131, 262–273.28541079 10.1037/bne0000199PMC5481199 | — | — | — |
| McCance-KatzEF (2018) The Substance Abuse and Mental Health Services Administration (SAMHSA): new directions. Psychiatric Services, 69, 1046–1048.30099944 10.1176/appi.ps.201800281 | — | — | — |
| McDonaldJH (2014) Handbook of biological statistics, 3rd edition. Baltimore, MD: Sparky House Publishing. | — | — | — |
| McLoughlinG, GyurkovicsM, PalmerJ & MakeigS (2022) Midfrontal theta activity in psychiatric illness: an index of cognitive vulnerabilities across disorders. Biological Psychiatry, 91, 173–182.34756560 10.1016/j.biopsych.2021.08.020 | — | — | — |
| MeuwissenAS & EnglundMM (2016) Executive function in at-risk children: importance of father-figure support and mother parenting. Journal of Applied Developmental Psychology, 44, 72–80.27175046 10.1016/j.appdev.2016.04.002PMC4861318 | — | — | — |
| MeyersJ, McCutcheonVV, PandeyAK, KamarajanC, SubbieS, ChorlianD (2019) Early sexual trauma exposure and neural response inhibition in adolescence and young adults: trajectories of frontal theta oscillations during a go/no-go task. Journal of the American Academy of Child and Adolescent Psychiatry, 58, 242–255.30738551 10.1016/j.jaac.2018.07.905PMC6537865 | — | — | — |
| MuthénLK & MuthénBO (1998–2019) Mplus user’s guide, 8th edition. Los Angeles, CA: Muthén & Muthén. | — | — | — |
| NelsonDA & CoyneSM (2009) Children’s intent attributions and feelings of distress: associations with maternal and paternal parenting practices. Journal of Abnormal Child Psychology, 37, 223–237.18792775 10.1007/s10802-008-9271-3 | — | — | — |
| PandeyAK, KamarajanC, ManzN, ChorlianDB, StimusA & PorjeszB (2016) Delta, theta, and alpha event-related oscillations in alcoholics during go/NoGo task: neurocognitive deficits in execution, inhibition, and attention processing. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 65, 158–171.26456730 10.1016/j.pnpbp.2015.10.002PMC4679474 | — | — | — |
| PandeyG, SeayMJ, MeyersJL, ChorlianDB, PandeyAK, KamarajanC (2020) Density and dichotomous family history measures of alcohol use disorder as predictors of behavioral and neural phenotypes: a comparative study across gender and race/ethnicity. Alcoholism, Clinical and Experimental Research, 44, 697–710.31957047 10.1111/acer.14280PMC8357185 | — | — | — |
| PaquetteD, CyrC, GaumonS, St-AndréM, Émond-NakamuraM, BoisjolyL (2021) The activation relationship to father and the attachment relationship to mother in children with externalizing behaviors and receiving psychiatric care. Psychiatry International, 2, 59–70. | — | — | — |
| ParolinM, SimonelliA, MapelliD, SaccoM & CristofaloP (2016) Parental substance abuse As an early traumatic event. Preliminary findings on neuropsychological and personality functioning in young drug addicts exposed to drugs early. Frontiers in Psychology, 7, 887.27378983 10.3389/fpsyg.2016.00887PMC4909766 | — | — | — |
| PattonJH, StanfordMS & BarrattES (1995) Factor structure of the Barratt impulsiveness scale. Journal of Clinical Psychology, 51, 768–774.8778124 10.1002/1097-4679(199511)51:6<768::aid-jclp2270510607>3.0.co;2-1 | — | — | — |
| PetersenIT, HoyniakCP, BatesJE, StaplesAD & MolfeseDL (2018) A longitudinal, within-person investigation of the association between the P3 ERP component and externalizing behavior problems in young children. Journal of Child Psychology and Psychiatry, 59, 1044–1051.30255499 10.1111/jcpp.12975PMC6467251 | — | — | — |
| PiotrowskaPJ, StrideCB, CroftSE & RoweR (2015) Socioeconomic status and antisocial behaviour among children and adolescents: a systematic review and meta-analysis. Clinical Psycholical Review, 35, 47–55.10.1016/j.cpr.2014.11.00325483561 | — | — | — |
| PorjeszB, RangaswamyM, KamarajanC, JonesKA, PadmanabhapillaiA & BegleiterH (2005) The utility of neurophysiological markers in the study of alcoholism. Clinical Neurophysiology, 116, 993–1018.15826840 10.1016/j.clinph.2004.12.016 | — | — | — |
| PuhlmannLMC, DeromeM, MorosanL, KilicelD, VrtičkaP & DebbanéM (2021) Longitudinal associations between self-reported attachment dimensions and neurostructural development from adolescence to early adulthood. Attachment & Human Development, 1–19. 10.1080/14616734.2021.199362834730475 | — | — | — |
| RaleyS & BianchiS (2006) Sons, daughters, and family processes: does gender of children matter? Annual Review of Sociology, 32, 401–421. | — | — | — |
| RamchandaniP, SteinA, EvansJ, O’ConnorTG & ALSPAC Study Team. (2005) Paternal depression in the postnatal period and child development: a prospective population study. Lancet, 365, 2201–2205.15978928 10.1016/S0140-6736(05)66778-5 | — | — | — |
| RangaswamyM, JonesKA, PorjeszB, ChorlianDB, PadmanabhapillaiA, KamarajanC (2007) Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. International Journal of Psychophysiology, 63, 3–15.17129626 10.1016/j.ijpsycho.2006.10.00PMC2020838 | — | — | — |
| ReczekaC, ThomeerMB, KisslingA & LiuH (2017) Relationships with parents and adult children’s substance use. Addiction Behavior, 65, 198–206.10.1016/j.addbeh.2016.10.014PMC561844327835859 | — | — | — |
| ReichW, EarlsF & PowellJ (1988) A comparison of the home and social environments of children of alcoholic and non-alcoholic parents. British Journal of Addiction, 83, 831–839.3207941 10.1111/j.1360-0443.1988.tb00518.x | — | — | — |
| RosenquistJN, MurabitoJ, FowlerJH & ChristakisNA (2010) The spread of alcohol consumption behavior in a large social network. Annals of Internal Medicine, 152, 426–433, W141.20368648 10.1059/0003-4819-152-7-201004060-00007PMC3343772 | — | — | — |
| SchriberRA & GuyerAE (2016) Adolescent neurobiological susceptibility to social context. Developmental Cognitive Neuroscience, 19, 1–18.26773514 10.1016/j.dcn.2015.12.009PMC4912893 | — | — | — |
| Sosic-VasicZ, KrönerJ, SchneiderS, VasicN, SpitzerM & StrebJ (2017) The association between parenting behavior and executive functioning in children and young adolescents. Frontiers in Psychology, 8, 472.28424644 10.3389/fpsyg.2017.00472PMC5371664 | — | — | — |
| SouthSC, KruegerRF, JohnsonW & IaconoWG (2008) Adolescent personality moderates genetic and environmental influences on relationships with parents. Journal of Personality and Social Psychology, 94, 899–912.18444746 10.1037/0022-3514.94.5.899PMC2603027 | — | — | — |
| StarrelsME (2016) Gender differences in parent-child relations. Journal of Family Issues, 15, 148–165. | — | — | — |
| SteketeeM, AussemsC & MarshallIH (2021) Exploring the impact of child maltreatment and Interparental violence on violent delinquency in an international sample. Journal of Interpersonal Violence, 36, NP7319–NP7349.30678540 10.1177/0886260518823291 | — | — | — |
| SuJ, KuoSI, AlievF, GuyMC, DerlanCL, EdenbergHJ (2018) Influence of parental alcohol dependence symptoms and parenting on adolescent risky drinking and conduct problems: a family systems perspective. Alcoholism, Clinical and Experimental Research, 42, 1783–1794.29969154 10.1111/acer.13827PMC6120770 | — | — | — |
| TeicherMH & SamsonJA (2016) Annual research review: enduring neurobiological effects of childhood abuse and neglect. Journal of Child Psychology and Psychiatry, 57, 241–266.26831814 10.1111/jcpp.12507PMC4760853 | — | — | — |
| TeicherMH, SamsonJA, AndersonCM & OhashiK (2016) The effects of childhood maltreatment on brain structure, function and connectivity. Nature Reviews. Neuroscience, 17, 652–666.27640984 10.1038/nrn.2016.111 | — | — | — |
| TottenhamN (2014) The importance of early experiences for neuro-affective development. Current Topics in Behavioral Neurosciences, 16, 109–129.24264369 10.1007/7854_2013_254PMC4021037 | — | — | — |
| Van LissaCJ, KeizerR, Van LierPAC, MeeusWHJ & BranjeS (2019) The role of fathers’ versus mothers’ parenting in emotion-regulation development from mid-late adolescence: disentangling between-family differences from within-family effects. Developmental Psychology, 55, 377–389.30570297 10.1037/dev0000612 | — | — | — |
| WhittleS, SimmonsJG, DennisonM, VijayakumarN, SchwartzO, YapMB (2014) Positive parenting predicts the development of adolescent brain structure: a longitudinal study. Developmental Cognitive Neuroscience, 8, 7–17.24269113 10.1016/j.dcn.2013.10.006PMC6990097 | — | — | — |
| WhittleS, VijayakumarN, DennisonM, SchwartzO, SimmonsJG, SheeberL (2016) Observed measures of negative parenting predict brain development during adolescence. PLoS One, 11, e0147774.26824348 10.1371/journal.pone.0147774PMC4732618 | — | — | — |
| WilkinsonA, LantosH, McDanielT & WinslowH (2019) Disrupting the link between maltreatment and delinquency: how school, family, and community factors can be protective. BMC Public Health, 19, 588.31101102 10.1186/s12889-019-6906-yPMC6525373 | — | — | — |
| YoderJR, BrissonD & LopezA (2016) Moving beyond fatherhood involvement: the association between Father & Child Relationship Quality and youth delinquency trajectories. Family Relations, 65, 462–476. | — | — | — |
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | — | 2023 | → |