Significant genetic correlation with AD in EU was observed for 17 traits after correction for multiple testing (p < 1.11E-3 for 45 tested traits; Figure 3; Supplementary Table S6). The largest positive correlations were with ever smoking tobacco (rg = 0.708, SE = 0.134, p = 1.3E-7) and lifetime cannabis use (rg = 0.793, SE = 0.217, p = 2.5E-4), and with other psychiatric disorders, especially schizophrenia (rg = 0.357, SE = 0.054, p = 3.2E-11), ADHD (rg = 0.444, SE = 0.097, p = 4.2E-6), and depression (rg = 0.561, SE = 0.085, p = 3.5E-11). Educational attainment (rg = −0.468, SE = 0.066, p = 9.7E-13) and age at first birth (higher values indicate that participants were older when they had their first child; rg = −0.626, SE = 0.104, p = 2.0E-9) showed significant inverse genetic correlation with AD suggesting that liability to AD risk was genetically related to lower educational attainment and lower age at which the participant had his or her first child.
