Liability-scale SNP-heritability of AD was estimated at h2g = 0.090 (SE = 0.019, z = 4.80, p = 8.02E-7) in the meta-analysis of unrelated EU samples. Exclusion of the ADH1B locus did not substantially modify this estimate (h2g = 0.089, SE = 0.0185). Nominally significant polygenic signal for the meta-analysis of unrelated AA individuals was observed based on LDSR with scores computed from 1000 Genomes African populations (z = 2.12, p = 0.017), but the quantitative estimate of h2g was unstable depending on the choice of reference panel, reflecting the challenge of correctly specifying LDSR and robustly modelling LD for the AA population (Supplementary Information A11).
