There was limited genome-wide evidence for heterogeneity across all cohorts, within ancestry, between ancestries, or between study designs within ancestry (Supplementary Information A8; Supplementary Figures S6–S8). Evidence for inflation from population stratification or other confounding was also limited in the discovery meta-analysis (lambda = 0.962; Supplementary Figure S9) and within EU (lambda = 1.053, LD score regression [LDSR] intercept = 1.018) and AA (lambda = 1.007, LDSR intercept = 0.991-0.997; Supplementary Information A11). Gene-level association testing with MAGMA15 did not identify any additional significant genes in EU or AA (Supplementary Table S5, Supplementary Information A12), likely due to lack of power.
