PGSs were derived based on GWAS summary statistics of a prior structural equation model (40), which identified three genetically informative latent factors underlying a set of 18 normative and problematic AUBs. These factors represented 1) chronic and severe alcohol Problems, 2) BeerPref, a decreasing pattern of alcohol use/problems later in life marked by a preference for drinking beer and drinking without meals, and 3) overall quantity and frequency of Consumption of varied alcoholic beverage types. To examine broad as well as alcohol-specific influences, an additional PGS was derived to index 4) EXT, based on a GWAS meta-analysis of impulsivity-related traits and substance use (9).
