Several patterning factors were altered in BP vs control neurons. HOXA1, A6 and A7 that are expressed in the cerebellum and brainstem were significantly increased in control neurons, consistent with clinical reports of cerebellar hypoplasia20,21,55 in BP. Of transcripts associated with circadian rhythm, TIPIN, PENK and TAC1 were expressed at significantly higher levels in BP vs control neurons; whereas in iPSC NPAS2 was expressed at significantly lower levels in BP vs controls; CRY1 and RORA were expressed at higher levels.
