Consistent with our hypothesis, the proliferation of glioma cells in the LINC00665+ + YY2− group was significantly decreased compared with that in the LINC00665+ + YY2+ group (Figure 5E). However, there was a higher ratio of apoptotic cells in the LINC00665+ + YY2− group compared with that in the LINC00665+ + YY2+ group (Figure 5F). Moreover, glioma cells in LINC00665− + YY2+ group showed increased migration and invasion rates compared with those in the LINC00665− + YY2− group (Figure 5G). These results clarified that LINC00665 also inhibited YY2 mRNA degradation through the SMD pathway to regulate the malignant behaviors of glioma cells.
