In a two-bottle free-choice paradigm with limited access to ethanol, the preference for ethanol was significantly reduced only in Il1rn null male mice [main effect of genotype: F(1,135) = 85, p<0.001] (Fig. 3b). Amount of ethanol consumed was significantly reduced in Ctss and Il1rn mutant male mice. Total fluid intake was reduced in B2m, Ctss and Il6 null male mice and increased in Cd14 and Il1rn knockout male mice (for complete results see Supplemental Fig. 5; for detailed statistics see Supplemental Table 7).
