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Chunk #23 — 3. Results — 3.4 Adjusted associations of lifetime internalizing and externalizing psychopathology with clinical course and presentation of alcohol dependence

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Gender differences in the relationship of internalizing and externalizing psychopathology to alcohol dependence: likelihood, expression and course.
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After adjusting for sociodemographics and other comorbidity, the associations of internalizing and externalizing psychopathology with the expression and course of alcoholism showed very few gender differences for the categories of IO and EO (Table 4). IO had a negative association with largest quantity of drinks that was limited to males, and EO more strongly increased the odds of alcohol treatment among women than men (OR of 5.5 versus 2.1, p=.009). In contrast, BIE showed stronger positive associations (p<.05) for women than men with most measures of alcohol consumption, as well as with early and rapid onset of alcoholism and the likelihood of alcohol treatment (OR of 4.2 versus 2.4, p=.024).