Chunk #53 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.2 Ionotropic Glutamate Receptor Expression Differences (Table 2)

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Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.

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Overall, periadolescent binge-like drinking decreased gene expression for certain NMDA receptor subunits in the DRN, but increased particular AMPA, delta, and kainate receptor subunits within this region as well. Ethanol self-administration by adult P rats did not downregulate any NMDA receptor subunits in the AcbSh but did upregulate an AMPA, delta, and NMDA-receptor subunit.