Chunk #54 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.3 Expression Differences for Glutamate Transporters, Enzymes, and Postsynaptic Density (Table 3)
One of the most striking findings is that periadolescent binge-like drinking significantly downregulated gene expression for only three ancillary proteins (Mpp5, a MAGUK subfamily member, by ~30%; as well asVglut2 and Vglut3 by ~2-fold in the DRN); while upregulating expression levels for Homer3 and Slc1a1 in the CeA along with nine genes from the PSD (e.g., Homer3 ~4-fold and Tjp3 ~2.5-fold), as well as all three Shanks, two glutamate transporters (e.g., Slc1a6 ~3-fold), and two glutamate carriers in the DRN.213
