Two large subdivisions of prefrontal cortex are considered important in normal DR and DA performance. In both the human and nonhuman primate literature, evidence suggests that the functions related to successful DR performance rely more heavily on the integrity of the dorsolateral prefrontal system of the brain (located close to the skull near the temples), whereas those functions related to successful DA performance rely more heavily on the integrity of the orbitofrontal system of the brain (located behind and above the eyes).
