Chunk #10 — Results — GWAS meta-analyses

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Item-level analyses reveal genetic heterogeneity in neuroticism.

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The 493 lead SNPs implicated 908 genes through positional mapping, eQTL mapping and/or chromatin interactions (see Methods; Supplementary Data 18–30). Of these 908 genes, 473 were only associated to one or more individual item(s) and not to the sum-score3,4,21,22 (Supplementary Fig. 18a).