In the 13 phenotypes, a total of 16,825 SNPs were genome-wide significant (GWS: P < 5 × 10−8), of which 2,474 were located in inversions on chromosomes 8 and 17, as reported previously for the neuroticism sum-score3,18,19. All GWS variants had the same direction of effect in both meta-analyzed samples. The 16,825 detected variants tagged 493 lead SNPs (see Methods for definition of lead SNPs), mapping to 255 independent genomic regions (based on clumping using an r2 threshold of 0.1; Supplementary Datas 2–17; Supplementary Figs. 4–17; see Methods; http://fuma.ctglab.nl/20). Of the total 255 regions, 117 were GWS for the sum-score, and 6 to 44 regions (median = 32) were GWS for individual items. Genetic signal varied considerably between items, with some (e.g., LONE, SUF-NERV) showing only a few GWS associations, while others (e.g., IRR, MIS, MOOD, NERV-FEEL, WORRY) showed > 35 GWS genetic regions. Furthermore, of all 255 regions, 138 were GWS in item-level analyses only and not for the sum-score (Supplementary Data 2), and 42 were GWS in the sum-score analysis while no GWS association was observed for any of the items.
