Having replicated the genetic heterogeneity in the set of neuroticism items, we moved on, for reasons of robustness, to conduct meta-analysis on the GWAS results of the two samples for all 12 items (N range: 366,301–375,913) and the sum-score (N = 380,060) to allow comparison between item-level GWAS results and results obtained in GWAS of the sum-score (Supplementary Table 5).
