Protein S-palmitoylation plays an essential role in the function of both oncogenes and tumor suppressors (Resh, 2017). S-palmitoylation is mediated by a family of 23 members encoded by ZDHHC genes. An increasing number of studies have indicated that dysfunction and/or dysregulation of the ZDHHC proteins are important in tumorigenesis, such as ovarian cancer (Yuan et al., 2020), glioma (Chen et al., 2017, 2020b; Codony-Servat et al., 2019), and kidney renal clear cell carcinoma (Liu et al., 2020). In lung cancer, the screening of ZDHHCs has been performed in cell lines, but has not been evaluated in tissues from patients (Tian et al., 2015). Herein, we used high-throughput data of LUAD patients to identify key ZDHHCs from the ZDHHC family of palmitoyl S-acyltransferases. The data source including RNA-seq data of TCGA, microarray series from GEO, and mass spectrometry-based proteomic data generated by CPTAC. Among the differential expression ZDHHCs, ZDHHC5 was the only gene with prognostic value.
