Since ZDHHC5 is not the only ZDHHC protein with nuclear localization, we also performed correlation analysis to define the specificity of the effects of ZDHHC5 and INCENP (Figure 5C). The Pearson’s correlation analysis showed that ZDHHC5 was the only ZDHHC protein positively correlated with INCENP gene expression. Although ZDHHC16 also showed nuclear localization, its gene expression was negatively associated with INCENP. Accumulating evidence has indicated that the nuclear translocation of ZDHHC5 plays an important role in the regulation of many biological processes including S-palmitoylation, and its down-regulation is almost certainly involved in LUAD tumorigenesis.
