We first compared our gene association statistics with postmortem brain gene expression profiles from individuals with three psychiatric disorders (ASD, BD, SCZ)40. We found a significant overlap between common variation affected genes and differentially expressed genes (DEG) in SCZ (Extended Data Fig. 6a). SCZ-associated genes were also enriched for ASD DEG. In addition, ADHD-associated genes were enriched for ASD DEGs, recapitulating a shared genetic relationship between these two neurodevelopmental disorders41.
