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Chunk #51 — Online Methods — Statistical methods — Monogenic blood pressure gene lookups

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
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The UKB arrays include some rare coding variants for monogenic disorders. We collate a list of all specific mutation variants within genes known to be associated with monogenic BP disorders19. Results from the UKB association analyses for all three BP traits are extracted for any of these SNVs directly covered within the UKB dataset (Supplementary Table 14). Note that a search of proxies did not augment the list of available variants, so results are reported for the specific variants only.