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Chunk #22 — 3. Results — 3.1. Effects of ethanol on protein levels in P rats

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Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study.
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Among the 22 proteins that were significantly different in the ACB-shell between the ethanol-treated and saline-treated P rats (Table 2), there were 5 proteins that were similarly changed in the ACB-shell of ethanol- and saline- treated NP rats (Table 3), and no proteins that changed in the opposite direction. There were 9 proteins that were similarly changed by ethanol treatment in the ACB-shell of P and W rats (Tables 1 and 4), of which 3 were also in common with NP rats (i.e., guanine nucleotide-binding protein G(i) alpha-1 subunit, phosphoglucomutase-1 and WD repeat protein 1). Therefore, it appears that ethanol altered the levels of 11 of 22 proteins uniquely in the ACB-shell of P rats.