Repeated administration of ethanol significantly (p-values < 0.015; q-values < 0.06; fold change ≥ 1.15) altered the levels of 128 proteins in the ACB-shell of NP rats (Table 3). Most of the changes were in the range of 1.15- to 1.35-fold, with 2.5 more proteins having higher than lower levels in the ethanol group. Two general classes of proteins (i.e., Histones and myelin basic proteins) had differences of approximately 1.3-fold between the control and ethanol groups, with all proteins in both classes having higher expression in the ethanol treated group (Table 3). In addition, there were several calcium-calmodulin proteins, guanine nucleotide binding proteins and Ras-related proteins that also had higher expression levels in the ACB-shell of the ethanol than saline group of NP rats.
