Repeated administration of ethanol significantly (p < 0.015; q-values < 0.25; fold change ≥ 1.15) altered the levels of 22 proteins in the ACB-shell of P rats (Table 2). Most of the changes were in the range of 1.15- to 1.25-fold, with approximately equal numbers of proteins with higher and lower levels in the ethanol-treated group. Neuronal guanine nucleotide exchange factor (Ngef) had the highest fold change (1.65 × higher in the ethanol treated group). GO analysis did not yield any significant biological processes (BP) or molecular function (MF) categories, containing at least 5 proteins.
