The genome-wide data available from 23andMe and EAGLE/QIMR showed similar trends for replication. The genetic correlation between EAGLE/QIMR and the ADHD GWAS was extremely strong (rg = 0.970, SE = 0.207, P = 2.66 × 10−6) and not significantly different from one (one-sided P = 0.442). Genetic correlation with 23andMe was weaker but still strongly positive (rg = 0.653, SE = 0.114, P = 1.11 × 10−8), although also significantly less than 1 (one-sided P= 1.17 × 10−3). To explore this lower correlation we evaluated the genetic correlation between 23andMe and traits from LD Hub (see URLs)42 to potentially identify differences in the profile of genetic correlation compared to the ADHD GWAS (Online Methods). This comparison identified striking differences (Supplementary Table 14), most notably that the 23andMe GWAS show little to no genetic correlation with college completion (rg = 0.056, compared to rg = −0.54 for the primary ADHD GWAS; approximate P = 1.1 × 10−9 for difference) and other education-related phenotypes. Genetic correlations with obesity-related phenotypes were similarly smaller for the 23andMe cohort. The one domain where 23andMe exhibited
