posterior probability>90% in seven brain tissues (amygdala m=0.99; anterior cingulate cortex m=1; caudate m=1; cortex m=0.99; hypothalamus m=1; nucleus accumbens m=1, putamen m=0.99; Supplementary Figure 2A). The rs9291211×BEND4 eQTL showed posterior probabilities>90% in two brain tissues (caudate m=0.9; cortex m=1; Supplementary Figure 2B). We found significant association of rs9291211 with additional traits from the GWAS Atlas24 that were related to addictive substances including “alcohol usually taken with meals” (p=3.02×10−8), “frequency of consuming six or more units of alcohol” (p=2.78×10−4), “alcohol intake frequency” (p=5.91×10−4), and “cigarettes per day” (p=0.004) (Supplementary Table 3). The European-ancestry OEcontrols meta-analysis also showed enrichment for several brain development stages: post-conception weeks 9 (beta=0.04, p=1.28×10−4), 8 (beta=0.032, p=0.001), and 12 (beta=0.04, p=0.002) (Figure 2C). No result in the association and the enrichment analyses based on the African-ancestry OEcontrols GWAS meta-analysis survived multiple testing correction.
