Although rs9291211 showed only a “suggestive” GWS association with the OEcontrols phenotype, it was the strongest signal responsible for the significant BEND4 gene-based association. Accordingly, we tested its phenotypic spectrum in UK Biobank. This variant was associated with 22 phenotypes (FDR q<0.05; Figure 3, upper panel; Supplementary Table 7), which included dietary habits (e.g., UK Biobank Field ID: 6179 “Mineral and other dietary supplements [None of the above]”, p=1.68×10−8), anthropometric traits (e.g., UK Biobank Field ID: 1687 “Comparative body size at age 10”, p=7.58×10−8), behavioral traits (e.g., UK Biobank Field ID: 20127 “Neuroticism score”, p=3.12×10−6), physical outcomes (e.g., UK Biobank Field ID: 6152 “Hay fever, allergic rhinitis or eczema”, p=3.49×10−5), reproductive function (UK Biobank Field ID: 3581 Age at menopause [last menstrual period], p=8.40×10−5), and cognitive tests (e.g., UK Biobank Field ID: 404 “Reaction time [Duration to first press of snap-button in each round]”, p= 8.82×10−5).
