regions). Second generation PLINK [92] was employed to construct PRS for each phenotype, at the following 11 thresholds: p < 1 × 10−6, p < 1 × 10−4, p < 1 × 10−3, p < 1 × 10−2, p < 0.05, p < 0.1, p < 0.2, p < 0.3, p < 0.4, p < 0.5, p < 1.0. There are minor differences in the thresholding approach across the independent cohorts, i.e.,: while constructing the PRS for both ASB phenotypes, the Philadelphia Neurodevelopmental Cohort Study considered all aforementioned thresholds except p < 1 × 10−2, while the other cohorts considered all thresholds except p < 1.0 (see Supplementary Tables 9-14 for the exact thresholds). To correct for multiple testing, we applied a Bonferroni correction on the 22 tested phenotypes (α = 0.00227).
