To estimate the genetic correlation between ASB and a range of other phenotypes, we employed Linkage Disequilibrium Score Regression (LDSC) [30] through the LD Hub web portal (http://ldsc.broadinstitute.org/ldhub/) [93]. LD Hub, which is a centralized database of summary-level GWAS results, enables the screening of hundreds of traits. To maximize statistical power among the most likely candidate phenotypes, we focused on domains of traits that have been previously reported to be comorbid with ASB. Genetic correlations of ASB were thus calculated by selecting 68 phenotypes of health, physiological, personality, disorder and disease relevant outcomes in LD Hub. In addition, we manually ran genetic correlations analyses for a selection of traits that were not included in the LD Hub framework. Given their relevance for this study, we employed LDSC to examine the genetic correlation of ASB with FFM domains agreeableness, openness to experience and conscientiousness, by using data of the Genetics of Personality Consortium [94]. Similarly, we used data of the most recent GWAS meta-analysis on neuroticism [95] to compute the genetic correlation with ASB. Lastly, while excluding the iPSYCH/PGC samples (given
