Repeated administration of ethanol significantly (p < 0.015; q-values < 0.2; fold change ≥ 1.15) altered the levels of 28 proteins in the ACB-shell of W rats (Table 5). Most of the changes were in the range of 1.15- to 1.25- fold, with approximately equal numbers of proteins having increased and decreased levels in the ethanol versus saline group. Similar to the findings with P rats, neuronal guanine nucleotide exchange factor (Ngef) had the highest fold difference with 1.5-fold higher levels in the ethanol group. GO analysis did not yield any significant BP or MF categories, containing at least 5 proteins.
