Marker information, allele frequency and single marker allelic association results are displayed in Table 2 for 20 SNPs in the two GAD genes. In the total sample, no SNP in either GAD gene was associated with AD (other than allelic association test, genotypic tests including general genotype test, dominant & recessive models, and Cochran-Armitage trend test were also performed. No genotypic associations were found and results were not presented in Table 2). Among females, several SNPs in GAD2 showed modest association (P = 0.04) with AD, although the effects become non-significant after adjusting for false discoveries (Table 2).
