Genotyping was completed for 12 SNPs in GAD1 and 17 SNPs in GAD2. Among the 29 genotyped SNPs we excluded 1 with a low genotyping rate (<80%) and 8 with MAF < 0.01, leaving 9 in GAD1 and 11 in GAD2. The average genotyping call rate for these 20 SNPs analyzed was ranged from 94.3 to 95.5%. All SNPs retained in the analysis were in Hardy-Weinberg equilibrium (using a cutoff P-value of 0.001) in the overall sample and in controls alone. Among the 1105 genotyped individuals, 16 (9 cases, 7 controls) were removed from analysis because of genotyping call rates less than 50%. The sample included in the final analysis thus consisted of 566 AD cases and 523 controls. The average genotyping rate among these individuals is 95.84%.
