The magnitude of rg’s associated with the items assigned to the clusters depressed affect and worry varied substantially for many traits (e.g., depressive symptoms, subjective well-being). Some of the traits showed genetic overlap with items of one of the clusters, but not with items from the other cluster (e.g., anorexia, schizophrenia, educational attainment, ADHD), whereas a few traits even showed GWS genetic correlations with items in both clusters yet in opposite directions (e.g., BMI, waist and hip circumference). Smoking related phenotypes (i.e., ever smoker, smoking cessation) showed significant correlations only to items of the depressed affect cluster, and not to items of the worry cluster. These results clearly indicate that biological insight may be gained by analyzing these genetically homogeneous clusters separately.
