effect estimates (odds ratio) for association of allele dosage of the top hits with fracture risk were obtained from logistic regression models adjusted for age, age2 weight, sex, height and four principal components. The proportion of the fracture risk explained by FN-BMD was calculated from the regression coefficients as (βunadjusted - βBMDadjusted)/βunadjusted in a subset of replication samples for which both FN-BMD and complete fracture information was available.
