In children, 11 out of 16 PGSs were significantly correlated with mother-reported AGG in 7-year olds (Fig. 2) after correction for multiple testing. The scores explained between 0.036 and 0.44% of the phenotypic variance. The significant correlations consistently emerged when scores including SNPs with P values above 0.002 in the discovery GWAS were considered. In the retrospective assessments of adolescent CD, the PGS calculated at various thresholds (Fig. 3) explained up to 0.2% of the variance in symptom sum scores. Generally, CD is significantly predicted at most thresholds, although, as we would expect based on the SNP-heritability of AGGoverall, the proportion of explained variance is small.
