Many of these studies test multiple hypotheses and in some cases underpowered to do so, therefore there is a need for replication of these results. For example, our investigation of healthy human subjects has been used to test many different genetic hypotheses, so that if corrections for multiple testing across all of these different genes were applied, several results would not be considered statistically significant. In an effort to examine the reliability of our results we now have collected almost 400 subjects and are in the process of performing replication analyses.
