When we compared 76 (53 independent) SNPs from the AN results with 89 established BMI/obesity SNPs,61, 62 five SNPs (inside NEGR1, PTBP2, TMEM18, FTO and MC4R) had P<0.05 (binomial P=0.1906). Twenty-six of these 53 SNPs had the same direction of effect as originally reported (binomial P value=1) (Table S12). Thirteen of 15 SNPs associated with extreme obesity were extracted from our dataset and 9 of these were independent. Four of these 9 SNPs had the same direction of effect as originally reported (binomial P value=1) (Table S13). Three SNPs (in TMEM18, FTO and MC4R) had P<0.05 (binomial P value=0.0084), indicating modest enrichment of nominally associated SNPs from extreme obesity in our discovery dataset.
