iMO genes (Tables 1 and 2) with the functions of genes described in several comprehensive reviews on the genetics of AUD (Edenberg and Foroud, 2013, 2014; Palmer et al., 2012; Rietschel and Treutlein, 2013; Schuckit, 2014). As is true for individual genes, the most compelling evidence for a pathway important in iMOs and humans is for the alcohol-metabolizing machinery of ADH and ALDH. In addition, several other cellular processes also have strong support in iMOs and humans including signaling via dopamine, NPY, growth factors, and potassium channels (Tables 1 and 2). Thus, the 51 iMO–human-AUD genes in Table 4 probably under represent the functional overlap of findings from alcohol studies in iMOs and humans.
