Chunk #48 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Framingham Heart Study (FHS): The FHS is a three-generation, single-site, community-based, ongoing cohort study that was initiated in 1948. It now comprises three generations of participants including the Original cohort followed since 1948 (n=5,209)54, their Offspring and spouses of the offspring (n=5,216) followed since 197155; and children from the largest Offspring families enrolled in 2000 (Gen 3)56. Participants in the Original and Offspring cohorts are used in these analyses, but Gen 3 participants were not included since they are young (mean age 40±9 years in 2000) and none had developed Alzheimer’s Disease (AD). The Original cohort enrolled 5,209 men and women who comprised two-thirds of the adult population then residing in Framingham, Massachusetts. Survivors continue to receive biennial examinations. The Offspring cohort comprises 5,124 persons (including 3,514 biological offspring) who have been examined approximately once every 4 years. Almost all the FHS Original and Offspring participants are white/Caucasian. FHS participants had DNA extracted and provided consent for genotyping in the 1990s. All available eligible participants were genotyped at Affymetrix (Santa Clara, CA) through an NHLBI funded SNP-Health Association Resource (SHARe)
