Chunk #24 — RESULTS — Multivariate GWAS confirm a distinct genetic basis between alcohol consumption and misuse

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Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts.

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The results of our multivariate GWAS for Consumption and Problems are presented in Figure 3. We identified 8 independent loci that were associated with Consumption (Table S9). For Problems, we replicated 2 loci on chromosome 4, located in the ethanol metabolizing gene ADH1B (Table S10). The signal associated with the latent factors is convergent with that of the sum scores, with a few exceptions (Supplementary Material 6.1.1 and Tables S11–12).