The protocol, approved by the University of California, San Diego (UCSD) Human Protections Committee, began with a Campus Questionnaire emailed to all (∼4,000) entering freshmen. They were paid $10 to answer items adapted from the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) interview. These covered demography, drinking and drug use patterns, and related diagnoses from the Fourth Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV) (American Psychiatric Association, 1994). The SSAGA has repeat reliabilities and validities compared to additional instruments of ∼.80 (Bucholz et al., 1994; Hesselbrock et al., 1999). Respondents were considered for the next study phase if they had consumed alcohol in the prior month, never met criteria for alcohol or drug dependence, had no major medical problems, and were not taking medications that could affect their response to alcohol. They also answered questions from the Self-Rating of the Effects of Alcohol (SRE) instrument measuring LR as the average number of drinks for up to four effects (initial feeling any effect of alcohol, slurring speech, stumbling, and unwanted falling asleep) during the approximate first five
