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Chunk #11 — Materials and Methods — SNP genotyping

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GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.
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All SNPs were tested for Mendelian inheritance using the program PEDCHECK (O’Connell and Weeks, 1998). Marker allele frequencies and heterozygosities were computed using the program USERM13 (Boehnke, 1991). Markers were tested for Hardy-Weinberg equilibrium in independent individuals from the study sample using Haploview (Barrett et al., 2005) and were omitted from analysis if they deviated significantly (p < 0.001) from Hardy-Weinberg equilibrium.