At the gene level, we use Ingenuity Pathway Analysis (IPA) software (IPA®,QIAGEN Redwood City) to review genes with prior links to BP, based on annotation with the “Blood Pressure” Medline Subject Heading (MESH) term which is annotated to 684 genes. We also use IPA to identify genes which interact with BP MESH annotated genes, and evaluate genes for evidence of small molecule druggability based on queries of Chembl and Drug Gene Interaction database.
