We then perform overall enrichment testing across all loci. Firstly, we use DEPICT70 (Data-driven Expression Prioritized Integration for Complex Traits) to identify highly expressed tissues and cells within the BP loci. DEPICT uses a large number of microarrays (˜37k) to identify cells and tissues where the genes are highly expressed and uses precomputed GWAS phenotypes to adjust for co-founding sources. DEPICT provides a P-value of enrichment and false discovery rates adjusted P-values for each tissue/cells tested.
