The Gerrein et al (1973) six arm study compared unsupervised and supervised disulfiram intake (groups one and two) to two no disulfiram groups (groups three and four depending upon the frequency of clinic visits). Groups one and three were assigned weekly clinic visits and groups two and four biweekly clinic visits. The last two arms were not randomized and thus not included in our analyses. We compared the supervised (biweekly clinic visit) disulfiram group to the no disulfiram (also biweekly clinic visit) group and the unsupervised (weekly clinic visit) disulfiram group to the other no disulfiram (weekly clinic visit) group.
