Following QC procedures already carried out centrally by UKB, we exclude discordant SNVs and samples with QC failures, gender discordance and high heterozygosity/missingness. We further restrict our data to a subset of individuals of European ancestry. By applying kmeans clustering to the Principal Component Analysis (PCA) data a total of N=145,315 Europeans remain (Supplementary Fig. 15). We use the kinship data to exclude 1st and 2nd degree relatives, with N=141,647 unrelated individuals remaining. Finally we restrict our data to non-pregnant individuals with two automated BP measurements available, resulting in a maximum of N=140,886 individuals for analysis (Supplementary Note).
